反应详情

温度

85 °C

To a mixture of 3-(6-(3-chlorophenyl)-1-methyl-2,4-dioxo-1H-pyrrolo[3,2-d]pyrimidin-3(2H,4H,5H)-yl)propyl acetate (60 mg, 0.16 mmol), K2CO3 (110 mg, 0.80 mmol) in DMF (2 ml) was added 1-chloro-4-(chloromethyl)benzene (51 mg, 0.32 mmol). The reaction was heated at 85° C. for 2 h, cooled to RT then diluted with EA (20 mL) and water (20 mL). The organic layer was dried over Na2SO4 and concentrated to give 3-(5-(4-chlorobenzyl)-6-(3-chlorophenyl)-1-methyl-2,4-dioxo-1H-pyrrolo[3,2-d]pyrimidin-3(2H,4H,5H)-yl)propyl acetate (40 mg, 50% yield) as an oil. LCMS: MH+ 500 and TR=1.847 min. Used without further purification.

1. temperaturecooled to RT
2. dry with materialThe organic layer was dried over Na2SO4
3. concentrationconcentrated