反应详情

温度

80 °C

To a solution of 500 mg of 2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-hydroxymethyl-2H-pyrazole-3-carboxylic acid in 5 ml DMF 480 mg Cs2CO3 and 204 mg 1-Bromo-2-methoxy-ethane were added and the mixture was heated to 80° C. for 5 h. Then the mixture was acidified to pH 4 with aqueous HCl and filtered through a Chem Elut® cartridge by elution with ethyl acetate. After concentration the crude product was directly subjected to the next reaction step.

1. filtrationfiltered through a Chem Elut® cartridge by elution with ethyl acetate
2. concentrationAfter concentration the crude product
3. customwas directly subjected to the next reaction step