Water → HCID 67040926, compound

HRID 605201Notes

Reaction equation

HRID 605201 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1.CCN(C(C)C)C(C)C.[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][C:23]=1[N+:31]([O-:33])=[O:32].O>C1COCC1>[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:9][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:8][CH:7]=2)=[O:27])=[CH:24][C:23]=1[N+:31]([O-:33])=[O:32]

Participants

6

Reactant 4

HCID 962WaterHCID 99644-(Trifluoromethyl)anilineHCID 81531DiisopropylethylamineHCID 27833474-Fluoro-3-nitrobenzoyl chloride

Product 1

HCID 67040926HCID 67040926, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The title compound was prepared by dissolving 4-Trifluoromethyl-phenylamine (475 mg, 2.95 mmol) in THF (20 ml) at room temperature. To this solution was added Hunig's base (762 mg, 5.86 mmol) and then a solution of the product from Example 172a (600 mg, 2.95 mmol) in THF (10 mL) was added drop wise over 5 minutes. After complete addition the reaction mixture was allowed to stir at room temperature for 1 hr and was poured into water and the title compound collected by filtration (900 mg, 93%).

Workup

  1. additionAfter complete addition the reaction mixture
  2. filtrationthe title compound collected by filtration (900 mg, 93%)

Sources & evidence

ORD record
ord-1677ea2c0f964df591c94c1eb8b7f60a
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

Loading…