Hydrochloric Acid → HCID 67040379, compound

HRID 605218Notes

Reaction equation

HRID 605218 reaction equation
C1C2C(COC(=O)[NH:17][C:18]3[CH:23]=[CH:22][C:21]([S:24][C:25]4[CH:30]=[CH:29][C:28]([C:31](=[O:41])[NH:32][C:33]5[CH:34]=[N:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=5)=[CH:27][C:26]=4[NH:42][C:43]4[C:44]5[CH:52]=[CH:51][C:50]([CH:53]([CH3:55])[CH3:54])=[N:49][C:45]=5[N:46]=[CH:47][N:48]=4)=[CH:20][CH:19]=3)C3C(=CC=CC=3)C=2C=CC=1.O.[OH-].[Li+].Cl>O1CCOCC1.O.C(OCC)(=O)C>[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([S:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([NH:32][C:33]3[CH:34]=[N:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=3)=[O:41])=[CH:27][C:26]=2[NH:42][C:43]2[C:44]3[CH:52]=[CH:51][C:50]([CH:53]([CH3:55])[CH3:54])=[N:49][C:45]=3[N:46]=[CH:47][N:48]=2)=[CH:20][CH:19]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 67040487HCID 67040487, compound

Product 1

HCID 67040379HCID 67040379, compoundYield 77%

Reagents, catalysts & solvents 3

HCID 962WaterSolvent2×HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

A solution of the product of Example 201C (121.8 mg, 0.1603 mmol) in 1,4-dioxane (3 mL) was treated with a solution of lithium hydroxide monohydrate (13.5 mg, 0.3206 mmol) in water (1.5 mL) at ambient temperature, then heated at 70° C. for 30 minutes. The reaction was cooled to room temperature, diluted with ethyl acetate (75 mL) and water (30 mL), adjusted the aqueous pH to 6 with 1N aqueous hydrochloric acid, and separated the layers. The organic phase was washed with water (2×25 mL) and brine (25 mL), dried over anhydrous sodium sulfate, filtered, and concentrated by rotary evaporation in vacuo. Purification of the residue by silica gel flash chromatography with 6% methanol/methylene chloride afforded the title compound as a light yellow solid (66 mg, 77%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.34 (d, J=6.99 Hz, 6 H) 3.05-3.39 (m, 1 H) 3.83 (s, 3 H) 5.59 (s, 2 H) 6.64 (d, J=8.46 Hz, 2 H) 6.82 (d, J=8.82 Hz, 1 H) 6.88 (dd, J=7.35, 1.84 Hz, 1 H) 7.14 (d, J=8.46 Hz, 2 H) 7.57-7.69 (m, 1 H) 7.73-7.85 (m, 1 H) 7.89-7.99 (m, 1 H) 8.01 (dd, J=9.01, 2.76 Hz, 1 H) 8.48 (d, J=2.57 Hz, 1 H) 8.52-8.66 (m, 1 H) 8.83-8.98 (m, 1 H) 10.16 (s, 1 H) 10.20 (s, 1 H); MS (ESI+) m/z 538 (M+H)+, 560 (M+Na)+, (ESI−) m/z 536 (M−H)−.

Workup

  1. temperatureThe reaction was cooled to room temperature
  2. customseparated the layers
  3. washThe organic phase was washed with water (2×25 mL) and brine (25 mL)
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated by rotary evaporation in vacuo
  7. customPurification of the residue by silica gel flash chromatography with 6% methanol/methylene chloride

Sources & evidence

ORD record
ord-5d012aa573bf4952b415feb3ad62ed42
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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