Water → HCID 2649530, compound

HRID 605255Notes

Reaction equation

HRID 605255 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[N+:18]([O-:20])=[O:19].CCN(C(C)C)C(C)C.O>C1COCC1>[F:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:7]([C:5]2[S:6][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:8])=[CH:13][C:12]=1[N+:18]([O-:20])=[O:19]

Participants

6

Reactant 4

HCID 962WaterHCID 677684-Fluoro-3-nitroanilineHCID 81531DiisopropylethylamineHCID 6057125-Bromothiophene-2-carbonyl chloride

Product 1

HCID 2649530HCID 2649530, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from Example 241a (2.178 g, 10.25 mmol) was reacted with 4-fluoro-3-nitro-phenylamine (1.60 g, 10.25 mmol) dissolved in THF (25 mL) and Hunig's base (2.484 g, 19.22 mmol). Reaction mixture was stirred at room temperature for 1 hr at which time water was added and the title compound was collected by filtration (2.00 g, 78%).

Workup

  1. customReaction mixture
  2. additionwas added
  3. filtrationthe title compound was collected by filtration (2.00 g, 78%)

Sources & evidence

ORD record
ord-0427ecdeff674ac291c94d538c3bce14
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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