4-Methylbenzenethiol → HCID 67040447, compound

HRID 605260Notes

Reaction equation

HRID 605260 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:30])[C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=3)=[CH:14][C:13]=2[N+:31]([O-:33])=[O:32])=[CH:7][CH:6]=1)(C)(C)C.C([O-])([O-])=O.[K+].[K+].CC1C=CC(S)=CC=1>CN(C=O)C.O>[N+:31]([C:13]1[CH:14]=[C:15]([NH:18][C:19](=[O:30])[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:27])[F:28])[CH:21]=2)[CH:16]=[CH:17][C:12]=1[S:11][C:8]1[CH:7]=[CH:6][C:5]([CH3:1])=[CH:10][CH:9]=1)([O-:33])=[O:32]

Participants

6

Reactant 3

HCID 78114-MethylbenzenethiolHCID 11430Potassium CarbonateHCID 67040858HCID 67040858, compound

Product 1

HCID 67040447HCID 67040447, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

The product from Example 242b (600 mg, 1.828 mmol) was dissolved in DMF (20 mL) to which K2CO3 (505 mg, 3.656 mmol), and 4-methyl-benzenethiol (227 mg, 1.828 mmol) were added. This reaction mixture was then heated to 80° C. for 1 hr. At this time the reaction mixture was cooled to room temperature, diluted with water, and the title compound collected by filtration (611 mg, 77

Workup

  1. additionwere added
  2. temperatureAt this time the reaction mixture was cooled to room temperature
  3. filtrationthe title compound collected by filtration (611 mg, 77

Sources & evidence

ORD record
ord-90babf3768814973a413a92b0e6302fa
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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