反应详情

Lithium hydroxide (0.47 mL of a 0.5 N solution in H2O, 0.236 mmol) was added to a solution of the ester 11 (52 mg, 0.118 mmol) in THF (1.5 mL) at 23° C. The reaction mixture was stirred for 16 h, acidified with 1 N HCl and extracted with EtOAc. The organic portion was washed with brine (2×), dried (MgSO4), filtered and concentrated in vacuo. FCC (silica gel, 100% EtOAc) gave 36.2 mg (72%) of the free acid 12 as a light yellow, viscous oil.

1. extractionextracted with EtOAc
2. washThe organic portion was washed with brine (2×)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo