反应详情

Prepare essentially as described in EXAMPLE 15 using palladium(II) acetate (0.009 g, 0.04 mmol), tri-o-tolylphosphine (0.024 g, 0.08 mmol), copper (I) iodide (0.004 g, 0.02 mmol), 3-iodobenzonitrile (0.9 g, 3.93 mmol) and 5-vinylnicotinonitrile, (prepared essentially as described in PREPARATION 51), (0.715 g, 5.5 mmol) at 110° C. for 5 h. Add diethyl ether and wash with water three times. Filter the organic layer and concentrate to give the title compound (0.530g, 59%).

1. customPrepare essentially
2. custom(prepared essentially
3. customas described in PREPARATION 51), (0.715 g, 5.5 mmol) at 110° C. for 5 h
4. washAdd diethyl ether and wash with water three times
5. filtrationFilter the organic layer
6. concentrationconcentrate