Potassium Carbonate → 1-(5-Phenylethynyl-pyridin-3-yl)-ethanone O-methyloxime hydrochloride

HRID 606868Notes

Reaction equation

HRID 606868 reaction equation
[ClH:1].[O:2]([NH2:4])[CH3:3].[C:5]1([C:11]#[C:12][C:13]2[CH:14]=[C:15]([C:19](=O)[CH3:20])[CH:16]=[N:17][CH:18]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+]>>[ClH:1].[CH3:3][O:2][N:4]=[C:19]([C:15]1[CH:16]=[N:17][CH:18]=[C:13]([C:12]#[C:11][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:14]=1)[CH3:20]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 67047758HCID 67047758, compound

Product 1

HCID 866224701-(5-Phenylethynyl-pyridin-3-yl)-ethanone O-methyloxime hydrochlorideYield 38.2%

Procedure

Prepare essentially as described in EXAMPLE 6 using methoxylamine hydrochloride (700 mg, 8.4 mmol), 1-(5-phenylethynylpyridin-3-yl)-ethanone, (prepared as described in EXAMPLE 84), (230 mg, 1.05 mmol) and potassium carbonate (720 mg, 5.24 mmol) to give the title compound (115 mg, 38%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-1676f634ca404fd48870c77a47e04cfe
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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