Potassium Carbonate → HCID 86622477, compound

HRID 606881Notes

Reaction equation

HRID 606881 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]#[C:10][C:11]2[CH:12]=[C:13]([CH:17]=O)[CH:14]=[N:15][CH:16]=2)[CH:5]=[CH:6][C:7]=1[F:8].[ClH:19].[O:20]([NH2:22])[CH3:21].C(=O)([O-])[O-].[K+].[K+]>>[ClH:19].[CH3:21][O:20][N:22]=[CH:17][C:13]1[CH:14]=[N:15][CH:16]=[C:11]([C:10]#[C:9][C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=2)[CH:12]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 86076475HCID 86076475, compound

Product 1

HCID 86622477HCID 86622477, compoundYield 80%

Procedure

Prepare in a similar manner as described in EXAMPLE 6 using 5-(3,4-difluorophenylethynyl)-pyridine-3-carbaldehyde, (prepared essentially as described in EXAMPLE 101), (0.28 g, 1.15 mmol), methoxylamine hydrochloride (0.77 g, 9.21 mmol) and potassium carbonate (0.80 g, 5.76 mmol) to give the title compound (0.28 g, 80%).

Workup

  1. customPrepare in a similar manner
  2. custom(prepared essentially

Sources & evidence

ORD record
ord-63cf2c8c23854425a53683f8c5a70190
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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