Potassium Carbonate → HCID 86622479, compound

HRID 606882Notes

Reaction equation

HRID 606882 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]#[C:10][C:11]2[CH:12]=[C:13]([CH:17]=O)[CH:14]=[N:15][CH:16]=2)[CH:5]=[CH:6][C:7]=1[F:8].[ClH:19].[NH2:20][OH:21].C(=O)([O-])[O-].[K+].[K+]>>[ClH:19].[F:1][C:2]1[CH:3]=[C:4]([C:9]#[C:10][C:11]2[CH:12]=[C:13]([CH:17]=[N:20][OH:21])[CH:14]=[N:15][CH:16]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 86076475HCID 86076475, compound

Product 1

HCID 86622479HCID 86622479, compoundYield 35.4%

Procedure

Prepare in a similar manner as described in EXAMPLE 6 using 5-(3,4-difluorophenylethynyl)-pyridine-3-carbaldehyde (0.28 g, 1.15 mmol), (prepared essentially as described in EXAMPLE 101), hydroxylamine hydrochloride (0.64 g, 9.21 mmol) and potassium carbonate (0.80 g, 5.76 mmol) to give the title compound (0.120 g, 35%).

Workup

  1. customPrepare in a similar manner
  2. custom(prepared essentially

Sources & evidence

ORD record
ord-81141734d0224c359a473d08a6a09a0b
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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