Potassium Carbonate → 1-(5-Phenylethynyl-pyridin-3-yl)-ethanone oxime hydrochloride

HRID 606930Notes

Reaction equation

HRID 606930 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:15](=O)[CH3:16])[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:18].[NH2:19][OH:20].C(=O)([O-])[O-].[K+].[K+]>>[ClH:18].[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:15](=[N:19][OH:20])[CH3:16])[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 67047758HCID 67047758, compound

Product 1

HCID 866224851-(5-Phenylethynyl-pyridin-3-yl)-ethanone oxime hydrochloride

Procedure

Prepared in the same manner as described in EXAMPLE 6, using 1-(5-phenylethynyl-pyridin-3-yl)-ethanone, (prepared as described in EXAMPLE 166), (0.22 g, 0.97 mmol), hydroxylamine hydrochloride (0.54 g, 7.78 mmol) and potassium carbonate (0.67 g, 4.86 mmol) to give the free base of the title compound. Convert the free base to the hydrochloride salt as described in EXAMPLE 163 to give the title compound (0.112 g, 42%).

Workup

  1. customPrepared in the same manner

Sources & evidence

ORD record
ord-9430417098814bf9ac28402f5ce7b5c1
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

Loading…