Glycolide → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

HRID 611451Notes

Reaction equation

[CH2:1]1[O:8]C(=O)C[O:4][C:2]1=[O:3].[CH3:9][C@@H:10]1[O:17]C(=O)[C@H](C)[O:13][C:11]1=[O:12]>>[C:2]([OH:4])(=[O:3])[CH2:1][OH:8].[C:11]([OH:13])(=[O:12])[CH:10]([CH3:9])[OH:17]

Participants

Reactant 2

HCID 65432Glycolide

HCID 107983Lactide, L-

Product 1

HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

Procedure

Polymerization and post-treatment were performed in the same manner as in Polymer Preparation Example 1 except that a mixture of 196 g of glycolide and 4 g of L-(-)-lactide (product of Tokyo Kasei Kogyo Co., Ltd.) was used in place of 200 g of glycolide, thereby obtaining a glycolic acid-lactic acid copolymer [Polymer (P-2)]. The same process was conducted repeatedly to prepare a necessary amount of Polymer (P-2).

Workup

customPolymerization

Sources & evidence

ORD record: ord-68a0d821df824c0c925311da24f922a1
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06001439

Reaction notes

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