Hydrochloric Acid → HCID 19593899, compound

HRID 612319Notes

Reaction equation

HRID 612319 reaction equation
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[SH:7]CC(OC)=O.Cl.[CH3:14][CH2:15][O:16][CH2:17]C>>[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[CH2:14][C:15]([O:16][CH3:17])=[S:7]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 80803,4-dihydro-2H-pyranHCID 16907Methyl Thioglycolate

Product 1

HCID 19593899HCID 19593899, compound

Procedure

Dihydropyran (19 g, 230 mmol) was added dropwise to a solution of methyl mercaptoacetate (20 g, 188 mmol) in anhydrous ether (40 cm3) cooled in ice. Hydrogen chloride was passed into this solution until it began to feel warm and then the mixture was left to stand at room temperature overnight. Volatile components were removed under reduced pressure (50 C at 20 mmHg) to give the methyl tetrahydropyran-2-ylthioacetate in essentially quanitative yield. This material was sufficiently pure to be used without further purification.

Workup

  1. temperaturecooled in ice
  2. temperatureto feel warm
  3. waitthe mixture was left
  4. customVolatile components were removed under reduced pressure (50 C at 20 mmHg)

Sources & evidence

ORD record
ord-7cbe988171334b7685f3ebc5e09f3b77
Source dataset
uspto-grants-1999_12
Patent number
US06004531

Reaction notes

Loading…