Sodium Hydroxide → 3-Bromo-5-(trifluoromethyl)pyridin-2-amine

HRID 612371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 612371
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.[Br:12]Br.[OH-].[Na+]>C(O)(=O)C.CCOCC>[NH2:1][C:2]1[C:7]([Br:12])=[CH:6][C:5]([C:8]([F:9])([F:11])[F:10])=[CH:4][N:3]=1

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 7358622-Amino-5-(trifluoromethyl)pyridine

Produkt 1

HCID 130641553-Bromo-5-(trifluoromethyl)pyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 2-amino-5-trifluoromethylpyridine (9 g) in acetic acid (75 mL) at r.t. was added bromine (5.8 mL) slowly. After 1 h, the acid was neutralized by the careful addition of sodium hydroxide (10 N) at 0° C. The resulting orange precipitate was dissolved in ether and washed successively with saturated potassium carbonate, saturated Na2SO3 and brine, dried and concentrated. The residual solid was stirred vigorously in hexane for 1 h to provide, after filtration, the title compound as a white solid (10.2 g).

Aufarbeitung

  1. washwashed successively with saturated potassium carbonate, saturated Na2SO3 and brine
  2. customdried
  3. concentrationconcentrated
  4. customto provide
  5. filtrationafter filtration

Quellen und Nachweise

ORD-Eintrag
ord-bda624867c5e4b70bcc9f7d5e51aec6d
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06004950

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