Hydrochloric Acid → HCID 53805009, compound

HRID 612382Notes

Reaction equation

HRID 612382 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([S:16](Cl)(=[O:18])=[O:17])[CH:8]=[CH:9][C:10]=1[NH:11][S:12]([CH3:15])(=[O:14])=[O:13].[CH2:25]([NH:27][CH2:28][CH3:29])[CH3:26].Cl>ClCCl.N1C=CC=CC=1>[CH2:25]([N:27]([CH2:28][CH3:29])[S:16]([C:7]1[CH:8]=[CH:9][C:10]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:5]([O:4][C:3]2[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:2]=2[Cl:1])[CH:6]=1)(=[O:18])=[O:17])[CH3:26]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 8021DiethylamineHCID 23221647HCID 23221647, compound

Product 1

HCID 53805009HCID 53805009, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

3-(2,4-Dichlorophenoxy)-4-methylsulphonylaminobenzene-sulphonic acid chloride (1.08 g, 2.50 mmol) was dissolved in dichloromethane (5 ml) and at 0° C. added dropwise to a solution of diethylamine (0.30 ml, 2.51 mmol) in pyridine (20 ml). The mixture was stirred for 1 hour at 0° C., acidified with 1N HCl and extracted with ethyl acetate. The combined organic phases were dried over MgSO4 and the solvent was evaporated off. The residue was purified by chromatography (silica gel, CH2Cl2). Yield: 0.22 g=19% 13C (100 MHz, DMSO-d6) δ 149.98, 147.50, 136.21, 132.37, 130.43, 129.63, 129.21, 126.15, 123.56, 122.86, 122.72, 114.90, 41.77, 41.02, 14.02

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined organic phases were dried over MgSO4
  3. customthe solvent was evaporated off
  4. customThe residue was purified by chromatography (silica gel, CH2Cl2)

Sources & evidence

ORD record
ord-b2f826a8ce224d728a3644321fc6b8ff
Source dataset
uspto-grants-1999_12
Patent number
US06004948

Reaction notes

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