4-Methylmorpholine → HCID 53720479, compound

HRID 612539Notes

Reaction equation

HRID 612539 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([C:13]1[CH:18]=[CH:17][C:16]([CH:19]=CC(O)=O)=[CH:15][CH:14]=1)=[C:8]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1)[CH2:7][CH2:6]2.CN1CCO[CH2:35][CH2:34]1.ClC(OCC(C)C)=[O:41].[CH2:47]([NH:49][CH2:50][CH3:51])[CH3:48]>>[CH2:47]([N:49]([CH2:34][CH3:35])[C:50](=[O:41])[CH:51]=[CH:19][C:16]1[CH:17]=[CH:18][C:13]([C:9]2[C:10]3[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=3)[CH2:6][CH2:7][C:8]=2[C:24]2[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=2)=[CH:14][CH:15]=1)[CH3:48]

Participants

5

Reactant 4

HCID 79724-MethylmorpholineHCID 8021DiethylamineHCID 62365Isobutyl chloroformateHCID 54513474HCID 54513474, compound

Product 1

HCID 53720479HCID 53720479, compound

Procedure

The operation is carried out as in Example 7B using 400 mg of the acid prepared in Example 12, 0.23 ml of methylmorpholine, 0.2 ml of isobutyl chloroformate and 0.42 ml of diethylamine. 557 mg of expected product is obtained which is used as it is for the following example.

Sources & evidence

ORD record
ord-3f7ecbebe9234b23a5671e2b7d4d758d
Source dataset
uspto-grants-1999_12
Patent number
US06005003

Reaction notes

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