Dimethylformamide → HCID 19592550, compound

HRID 613483Notes

Reaction equation

HRID 613483 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([NH:12][C:13](=[O:22])[C:14]3[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:21])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.COCCN.[CH3:28][N:29](C)[CH:30]=O>>[Cl:21][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([Cl:20])[C:14]=1[C:13]([NH:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][CH:3]=[C:2]2[N:29]([CH3:30])[CH3:28])=[O:22]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 80182-MethoxyethylamineHCID 195925644-Chloro-8-(2,6-dichlorobenzoylamino)quinoline

Product 1

HCID 19592550HCID 19592550, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 4-chloro-8-(2,6-dichlorobenzoylamino)quinoline (130 mg) and 2-methoxyethylamine (210 mg) in dimethylformamide (1.5 ml) was heated for 5 hours at 100° C. The mixture was concentrated in vacuo, and the residue was purified by preparative thin layer chromatography to give 8-(2,6-dichlorobenzoylamino)-4-dimethylaminoquinoline (94 mg).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe residue was purified by preparative thin layer chromatography

Sources & evidence

ORD record
ord-4e823b747644468ca8b9f7f3f81edbd3
Source dataset
uspto-grants-1999_12
Patent number
US06008230

Reaction notes

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