Cyanide → HCID 21329855, compound

HRID 614028Notes

Reaction equation

HRID 614028 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([N:8]=[C:9]=[O:10])([CH3:7])[CH3:6].[C-]#N.[CH3:16][NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([NH:8][C:9](=[O:10])[N:17]([CH3:16])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([CH3:7])[CH3:6]

Participants

4

Reactant 3

HCID 5975CyanideHCID 7515N-MethylanilineHCID 21329846HCID 21329846, compound

Product 1

HCID 21329855HCID 21329855, compoundYield 86.4%

Conditions

Temperature
60 °C

Procedure

2.4 g of m-bromo-α,α-dimethylbenzyl isocyanate, prepared from the corresponding cyanide in the same way as in Synthesis Example 1, was added to 1.1 g of N-methylaniline and the mixture was heated at 60° C. for 2 hours. After allowing the reaction mixture to cool, the precipitated white crystals were separated by filtration and washed with n-hexane to obtain 3.0 g of the title compound.

Workup

  1. temperatureto cool
  2. customthe precipitated white crystals were separated by filtration
  3. washwashed with n-hexane

Sources & evidence

ORD record
ord-487f2e0f60a54abebef403c4ac9e1ed0
Source dataset
uspto-grants-1979_03
Patent number
US04143061

Reaction notes

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