Pyrrolidine → HCID 15593550, compound

HRID 615801Notes

Reaction equation

HRID 615801 reaction equation
O([C:8]([NH:10][C:11]1[S:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:19]=1)=[O:9])C1C=CC=CC=1.[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>CN(C=O)C>[N:20]1([C:8]([NH:10][C:11]2[S:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][C:14]=3[N:19]=2)=[O:9])[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 155935492-Phenoxycarbonylaminothiazolo[4,5-c]pyridine

Product 1

HCID 15593550HCID 15593550, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 2-phenoxycarbonylaminothiazolo[4,5-c]-pyridine (200 mg, 0.73 mmole) and pyrrolidine (0.3 ml) in DMF (2 ml) was heated at 70° C. for 30 minutes and evaporated in vacuo. The residue was triturated with ether to give 180 mg (98%) of the desired product. Mp. 218°~220° C.

Workup

  1. customevaporated in vacuo
  2. customThe residue was triturated with ether

Sources & evidence

ORD record
ord-c7d78b2eca174240872e3d1a60ae52c3
Source dataset
uspto-grants-1985_02
Patent number
US04500526

Reaction notes

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