Hydrochloric Acid → HCID 178517334, compound

HRID 616007Notes

Reaction equation

HRID 616007 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C:11]2[NH:15][N:14]=[CH:13][CH:12]=2)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1(OC2C=CC=CC=2)C=CC=CC=1.Cl>>[OH:9][C:8]1[C:7]2[CH:6]=[CH:5][CH:4]=[N:3][C:2]=2[N:15]2[N:14]=[CH:13][CH:12]=[C:11]2[N:10]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 7583Diphenyl EtherHCID 203708142-Chloro-N-(1H-pyrazol-5-yl)-3-pyridinecarboxamide

Product 1

HCID 178517334HCID 178517334, compound

Procedure

103 g. of 2-chloro-N-(1H-pyrazol-5-yl)-3-pyridinecarboxamide are suspended in 600 ml. of diphenyl ether and heated with stirring at 180° until the evolution of HCl gas ceases. After cooling to room temperature, 5-hydroxypyrazolo[1,5-a]pyrido[3,2-e]pyrimidine is filtered off, yield: 75 g. (88%); m.p. ≥ 300° (DMF).

Workup

  1. filtration5-hydroxypyrazolo[1,5-a]pyrido[3,2-e]pyrimidine is filtered off

Sources & evidence

ORD record
ord-6fa4dd07118f4827943d665068b28e59
Source dataset
uspto-grants-1978_02
Patent number
US04072680

Reaction notes

Loading…