Hydrochloric Acid → HCID 178509127, compound

HRID 616436Notes

Reaction equation

HRID 616436 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](=[CH2:11])[C:9]#[N:10])[CH2:3][CH2:2]1.[C:12]1([NH:18][NH2:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[O-]CC.[Na+].Cl>C(O)C>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH:8]2[CH2:11][N:18]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:19][C:9]2=[NH:10])[CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7516PhenylhydrazineHCID 2723922Sodium ethoxideHCID 27768472-(morpholin-4-ylmethyl)prop-2-enenitrile

Product 1

HCID 178509127HCID 178509127, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

α-Morpholinomethylacrylonitrile (54g) and phenylhydrazine (37g) were boiled under reflux with a solution of sodium ethoxide (7.5g sodium) in ethanol (250 ml) for two hours. A solid product was formed during the reaction. Dilute hydrochloric acid (160 ml 2N) was added and the solution was evaporated to dryness. The solid residue was extracted with dry ethanol and the product crystallised from the ethanol as colourless plates (melting point 204-5° C).

Workup

  1. customA solid product was formed during the reaction
  2. customthe solution was evaporated to dryness
  3. extractionThe solid residue was extracted with dry ethanol
  4. customthe product crystallised from the ethanol as colourless plates (melting point 204-5° C)

Sources & evidence

ORD record
ord-465026bf792f4d89b6396420473de100
Source dataset
uspto-grants-1978_02
Patent number
US04074051

Reaction notes

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