Dimethylformamide → HCID 21851289, compound

HRID 617171Notes

Reaction equation

HRID 617171 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][NH:20][C:21](=[O:32])[C:22]3[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][C:23]=3[N+:29]([O-:31])=[O:30])[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([O:35][CH3:36])=[C:7]([O:33][CH3:34])[CH:8]=2)[N:3]=1.C[N:38]1[CH2:42][CH2:41][CH2:40][C:39]1=O.CN(C)C=[O:47]>>[CH3:34][O:33][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[O:35][CH3:36])[N:3]=[C:2]([N:38]1[CH2:42][CH2:41][O:47][CH2:40][CH2:39]1)[N:11]=[C:10]2[N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][NH:20][C:21](=[O:32])[C:22]2[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][C:23]=2[N+:29]([O-:31])=[O:30])[CH2:14][CH2:13]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 13387N-methyl-2-pyrrolidoneHCID 21851294HCID 21851294, compound

Product 1

HCID 21851289HCID 21851289, compoundYield 83%

Procedure

The same procedure as in Example 1 was repeated, except that 2.5 g (4.87 mmol) of Compound m obtained in Reference Example 10 was used, and N-methylpyrrolidinone was used as the solvent in place of dimethylformamide, to give 2.29 g (yield: 83%) of Compound n as white crystals.

Workup

  1. customobtained in Reference Example 10

Sources & evidence

ORD record
ord-016acae43bb6462ca42aa86b9dfc7fc9
Source dataset
uspto-grants-1999_09
Patent number
US05948784

Reaction notes

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