反应详情

To an ice cold solution of ethyl isonipecotate (60 g, 0.382 mol) and triethylamine (38.65 g, 0.382 mol) in tetrahydrofuran (360 ml) was added dropwise benzoyl chloride (53.7 g, 0.382 mol) over a period of about 2 hours under nitrogen atmosphere. The reaction mixture was stirred for about 2 hours at the same temperature, and was filtered. The filtrate was evaporated in vacuo. The residue was partitioned between dichloromethane and water. The organic layer was dried over magnesium sulfate, and evaporated in vacuo. Crystallization from isopropyl alcohol gave the titled compound (90.9 g).

1. filtrationwas filtered
2. customThe filtrate was evaporated in vacuo
3. customThe residue was partitioned between dichloromethane and water
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customevaporated in vacuo
6. customCrystallization from isopropyl alcohol