Hydrochloric Acid → HCID 12017168, compound

HRID 617905Notes

Reaction equation

HRID 617905 reaction equation
Cl.C([N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([CH2:15][C:16]2[CH:25]=[CH:24][C:23]3[CH2:22][CH2:21][CH2:20][NH:19][C:18]=3[N:17]=2)[CH2:10]1)(OC(C)(C)C)=O>CCOC(C)=O>[N:17]1[C:18]2[NH:19][CH2:20][CH2:21][CH2:22][C:23]=2[CH:24]=[CH:25][C:16]=1[CH2:15][CH:11]1[CH2:12][CH2:13][CH2:14][NH:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12017167HCID 12017167, compound

Product 1

HCID 12017168HCID 12017168, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl gas was bubbled through a solution of 2-5 (0.8 g, 2.5 mmol) and EtOAc (15 mL) at 0° C. for 15 min. After an additional 15 min argon was passed through the solution for 15 min followed by concentration. The residue was azeotroped twice with ether to give 2-6 as a yellow solid.

Workup

  1. concentrationfollowed by concentration
  2. customThe residue was azeotroped twice with ether

Sources & evidence

ORD record
ord-d920c15dbaa64d3495582398874a3d8f
Source dataset
uspto-grants-1999_09
Patent number
US05952341

Reaction notes

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