Hydrochloric Acid → HCID 70071679, compound

HRID 618170Notes

Reaction equation

HRID 618170 reaction equation
C([C:5]([C:19](=[O:26])[CH:20]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]1)([C:16]([OH:18])=[O:17])[N:6]([C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)[CH:7]1[CH2:9][CH2:8]1)(C)(C)C.[ClH:27]>CCOC(C)=O>[ClH:27].[N:13]1[CH:12]=[CH:11][C:10]([N:6]([CH:7]2[CH2:9][CH2:8]2)[CH:5]([C:19](=[O:26])[CH:20]2[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]2)[C:16]([OH:18])=[O:17])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86754489HCID 86754489, compound

Product 1

HCID 70071679HCID 70071679, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Ester 22-3 (250 mg, 0.70 mmol) was suspended in EtOAc (25 mL), cooled to 0° and treated with HCl gas for 15 min. The resulting solution was stirred for 3.5 h then evaporated to give 22-4 as a white solid.

Workup

  1. temperaturecooled to 0°
  2. customthen evaporated

Sources & evidence

ORD record
ord-c2ca9af6db194801b29bccd30fbd9dc5
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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