Hydrochloric Acid → HCID 70248931, compound

HRID 618175Notes

Reaction equation

HRID 618175 reaction equation
[ClH:1].Cl.Cl.[CH2:4]([O:6][C:7](=[O:28])[CH2:8][C@H:9]([NH:16][C:17](=[O:27])[CH2:18][NH:19]C(OC(C)(C)C)=O)[C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH3:5]>CCOC(C)=O>[ClH:1].[ClH:1].[CH2:4]([O:6][C:7](=[O:28])[CH2:8][C@H:9]([NH:16][C:17](=[O:27])[CH2:18][NH2:19])[C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86754491HCID 86754491, compound

Product 1

HCID 70248931HCID 70248931, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl gas was passed through a solution of 24-1a (0.84 g, 2.4 mmol) in EtOAc (24 mL) at 0° C. for 15 min and the reaction mixture stirred for an additional 15 min. The reaction mixture was concentrated and the residue triturated with ether to give 24-2 as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue triturated with ether

Sources & evidence

ORD record
ord-b6dad2f2d1a441c48030e689795a1a9d
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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