Ammonium Hydroxide → HCID 178512338, compound

HRID 619017Notes

Reaction equation

HRID 619017 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:18])[CH:15]=[C:16]([Cl:17])[C:9]=3[CH:8]([CH:19]3[CH2:24][CH2:23][N:22]([C:25](=[O:43])[CH2:26][CH:27]4[CH2:31][CH2:30][N:29]([C:32](=[N:40][C:41]#[N:42])OC5C=CC=CC=5)[CH2:28]4)[CH2:21][CH2:20]3)[C:5]2=[N:6][CH:7]=1.[NH4+:44].[OH-]>CC(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:18])[CH:15]=[C:16]([Cl:17])[C:9]=3[CH:8]([CH:19]3[CH2:24][CH2:23][N:22]([C:25](=[O:43])[CH2:26][CH:27]4[CH2:31][CH2:30][N:29]([C:32](=[NH:44])[NH:40][C:41]#[N:42])[CH2:28]4)[CH2:21][CH2:20]3)[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 15435436HCID 15435436, compound

Product 1

HCID 178512338HCID 178512338, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
25 °C

Procedure

Dissolve the product of Example 7 in 2-propanol and add concentrated NH4OH. Stir the mixture at 25° C. for 24 h and then evaporate to dryness. Triturate the residue with Et2O (2×250 ml) and discard the ether. Chromatograph the resulting product on a silica gel column using 4% (10% concentrated NH4OH in CH3OH)--CH2Cl2 as the eluant to give the title compound.

Workup

  1. customevaporate to dryness
  2. customTriturate the residue with Et2O (2×250 ml)

Sources & evidence

ORD record
ord-4182922c03c04e409e125395467f2a27
Source dataset
uspto-grants-1999_09
Patent number
US05958890

Reaction notes

Loading…