Ammonium Hydroxide → HCID 178505164, compound

HRID 619022Notes

Reaction equation

HRID 619022 reaction equation
C1(O[C:8]([N:14]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]([N:22]3[CH2:27][CH2:26][CH:25]([CH:28]4[C:34]5=[N:35][CH:36]=[C:37]([Br:39])[CH:38]=[C:33]5[CH2:32][CH2:31][C:30]5[CH:40]=[C:41]([Cl:45])[CH:42]=[C:43]([Cl:44])[C:29]4=5)[CH2:24][CH2:23]3)=[O:21])[CH2:15]2)=[N:9][S:10]([CH3:13])(=[O:12])=[O:11])C=CC=CC=1.[NH4+:46].[OH-]>CC(O)C>[Br:39][C:37]1[CH:38]=[C:33]2[CH2:32][CH2:31][C:30]3[CH:40]=[C:41]([Cl:45])[CH:42]=[C:43]([Cl:44])[C:29]=3[CH:28]([CH:25]3[CH2:24][CH2:23][N:22]([C:20](=[O:21])[CH2:19][CH:16]4[CH2:17][CH2:18][N:14]([C:8](=[NH:46])[NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH2:15]4)[CH2:27][CH2:26]3)[C:34]2=[N:35][CH:36]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 70099995HCID 70099995, compound

Product 1

HCID 178505164HCID 178505164, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
25 °C

Procedure

The product of Example 26 is dissolved in 2-propanol and concentrated NH4OH is added. The mixture is stirred at 25° C. for 24 h and then evaporated to dryness. The residue is triturated with Et2O (2×250 ml) and the ether discarded. The resulting product is chromatographed on a silica gel column to give the title compound.

Workup

  1. customevaporated to dryness
  2. customThe residue is triturated with Et2O (2×250 ml)
  3. customThe resulting product is chromatographed on a silica gel column

Sources & evidence

ORD record
ord-ad75a8ab77e54b39ad1e33f3a099a171
Source dataset
uspto-grants-1999_09
Patent number
US05958890

Reaction notes

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