反应详情

温度

-5 °C

37.6 g 4-amino-2-(1-piperazinyl)-6,7-dimethoxyquinazoline and 15.8 g triethylamine are suspended in 400 ml methylene chloride. The suspension is cooled to -5° C. This suspension is stirred while 21.0 g tetrahydrofuran-2-carboxylic acid chloride are added drop by drop. The suspension is continued to be stirred for two hours at 0° C., thereafter the solvent is distilled off under vacuum. 200 ml methanol and 200 ml acetone are added to the residue. The resulting suspension is kept under reflux for 0.5 hours while stirring. Thereafter, it is cooled to 0° C. The product is isolated by filtration. 78 g of moist terazosin base are obtained.

1. additionare added drop by drop
2. distillationthe solvent is distilled off under vacuum
3. addition200 ml methanol and 200 ml acetone are added to the residue
4. temperatureunder reflux for 0.5 hours
5. stirringwhile stirring
6. temperatureThereafter, it is cooled to 0° C
7. customThe product is isolated by filtration