Potassium Carbonate → HCID 21846931, compound

HRID 619748Notes

Reaction equation

HRID 619748 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[C:21](F)[CH:20]=1>CN(C=O)C>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([N+:25]([O-:27])=[O:26])=[C:23]([S:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)[CH:24]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 696914-Chloro-2-fluoro-1-nitrobenzeneHCID 110519635-Isoquinolinethiol

Product 1

HCID 21846931HCID 21846931, compoundYield 92.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to the method in Example 10, a mixture of 5-isoquinolinethiol 500 mg (3.1 mmol), DMF 10 ml, potassium carbonate 700 mg (5.1 mmol) and 4-chloro-2-fluoronitrobenzene 800 mg (5.0 mmol) was stirred at room temperature for 2 hours, and 5-(5-chloro-2-nitrophenylsulfanyl)isoquinoline 910 mg (92.7%) was obtained.

Sources & evidence

ORD record
ord-1235be1f045a4acebd0213536da12b36
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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