Potassium Carbonate → HCID 135822815, compound

HRID 619752Notes

Reaction equation

HRID 619752 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].Cl[C:19]1[CH:28]=[C:27]2[C:22]([C:23](=[O:30])[NH:24][C:25]([CH3:29])=[N:26]2)=[CH:21][C:20]=1[N+:31]([O-:33])=[O:32]>CN(C=O)C>[CH:1]1[C:10]2[C:5](=[C:6]([S:11][C:19]3[CH:28]=[C:27]4[C:22]([C:23](=[O:30])[NH:24][C:25]([CH3:29])=[N:26]4)=[CH:21][C:20]=3[N+:31]([O-:33])=[O:32])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 110519635-IsoquinolinethiolHCID 135822814HCID 135822814, compound

Product 1

HCID 135822815HCID 135822815, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to the method in Example 10, a mixture of 5-isoquinolinethiol 150 mg (0.9 mmol), DMF 5 ml, potassium carbonate 250 mg (1.8 mmol) and 7-chloro-2-methyl-6-nitro-3,4-dihydro-4-quinazolinone 200 mg (0.8 mmol) was stirred at room temperature for 2 hours, and 7-(5-isoquinolylsulfanyl)-2-methyl-6-nitro-3,4-dihydro-4-quinazolinone 260 mg (83.7%) was obtained.

Sources & evidence

ORD record
ord-7654c496dde544688d7ee244722ba46b
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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