Potassium Carbonate → HCID 21846980, compound

HRID 619754Notes

Reaction equation

HRID 619754 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].Cl[C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][N:20]=1>CN(C=O)C>[N+:25]([C:22]1[CH:23]=[CH:24][C:19]([S:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)=[N:20][CH:21]=1)([O-:27])=[O:26]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 783082-Chloro-5-nitropyridineHCID 110519635-Isoquinolinethiol

Product 1

HCID 21846980HCID 21846980, compoundYield 78.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

According to the method in Example 10, a mixture of 5-isoquinolinethiol 1.12 g (6.9 mmol), DMF 20 ml, potassium carbonate 1.92 g (13.9 mmol) and 2-chloro-5-nitropyridine 1.00 g (6.3 mmol) was stirred at 100° C. for 2 hours, and 5-[(5-nitro-2-pyridyl)-sulfanyl)isoquinoline 1.40 g (78.4%) was obtained.

Sources & evidence

ORD record
ord-04eabab884264d659221f40bb0739e7a
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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