Piperidine → HCID 21247225, compound

HRID 620441Notes

Reaction equation

HRID 620441 reaction equation
[OH:1][CH:2]([CH2:12][Cl:13])[CH2:3][N:4]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[N:6]=[N:5]1.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>C1COCC1>[ClH:13].[OH:1][CH:2]([CH2:12][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:3][N:4]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[N:6]=[N:5]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 14458226HCID 14458226, compound

Product 1

HCID 21247225HCID 21247225, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 0.5 g of 1-(2'-hydroxy-3'-chloropropyl)-4-nitro-1,2,3-triazole and 3 g of piperidine in 10 ml of THF is refluxed for 1 hr with stirring. The solvent and excess piperidine are removed. The residue is dissolved in chloroform and washed with 5 ml of 1% NaOH solution. The solvent is evaporated to dryness, dissolved in dilute HCl solution washed with chloroform.

Workup

  1. temperatureis refluxed for 1 hr
  2. customThe solvent and excess piperidine are removed
  3. dissolutionThe residue is dissolved in chloroform
  4. washwashed with 5 ml of 1% NaOH solution
  5. customThe solvent is evaporated to dryness
  6. dissolutiondissolved in dilute HCl solution
  7. washwashed with chloroform

Sources & evidence

ORD record
ord-bd01c3a3905945a8ad02e3402ca0b75b
Source dataset
uspto-grants-1989_04
Patent number
US04820844

Reaction notes

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