反应详情

To a solution of 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(3-pyridyl)imidazole (1.40 g) in N,N-dimethylformamide (28 ml), was added phosphorus trichloride (0.83 ml), and the mixture was stirred for 2 hours at ambient temperature. Then, the solution was poured into water (150 ml), and stirred for an hour at ambient temperature. After neutrallized with aqueous sodium bicarbonate, resulting precipitates were collected by filtration. The precipitates were dried, dissolved in chloroform, and chromatographed on silica gel eluting with a mixture of chloroform and methanol. The fractions were collected, evaporated and triturated in diisopropyl ether to give 2-(2-methoxy-4-methylphenyl)-4-methyl-5-(3-pyridyl)imidazole (0.82 g)

1. stirringstirred for an hour at ambient temperature
2. customresulting
3. customprecipitates
4. filtrationwere collected by filtration
5. customThe precipitates were dried
6. dissolutiondissolved in chloroform
7. customchromatographed on silica gel eluting with a mixture of chloroform and methanol
8. customThe fractions were collected
9. customevaporated
10. customtriturated in diisopropyl ether