Methyl iodide → HCID 14100188, compound

HRID 621474Notes

Reaction equation

HRID 621474 reaction equation
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]2=[C:10]([NH:13][CH3:14])[NH:11][N:12]=[C:6]2[N:5]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[C:4]1=[O:23])[CH3:2].CI.[C:26](=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([N:3]1[C:8](=[O:9])[C:7]2=[C:10]([NH:13][CH3:14])[N:11]([CH3:26])[N:12]=[C:6]2[N:5]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)[C:4]1=[O:23])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 14100187HCID 14100187, compound

Product 1

HCID 14100188HCID 14100188, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 5-ethyl-3-methylamino-7-(4-methylbenzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (0.5 g, 1.6 mM), methyl iodide (0,46 g, 3.2 mM) and potassium carbonate (0,45 g, 3.2 mM) in DMF (8 ml) was stirred at 60° C. for 30 hours.

Sources & evidence

ORD record
ord-71ef4ce2e3d14b1b81daa88a1e4568bb
Source dataset
uspto-grants-1989_04
Patent number
US04824848

Reaction notes

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