反应详情

温度

60 °C

To a solution of 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (3.0 g) in N,N-dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 0.50 g). The mixture was heated at 60° C. with stirring for 20 minutes and cooled to ambient temperature. To the mixture was added isopropyl bromide (15 ml) with stirring, which was continued at ambient temperature for 5 hours, and at 50° C. for 25 hours. To the reaction mixture was added water, and extracted with ethyl acetate. The organic extract was washed with water, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated in diisopropyl ether to give 6-(3,4-dimethoxyphenyl)-2-isopropoxy-3-methyl-4-(3H)-pyrimidinone (2.73 g).

1. temperaturecooled to ambient temperature
2. stirringwith stirring
3. waitwhich was continued at ambient temperature for 5 hours
4. waitat 50° C. for 25 hours
5. extractionextracted with ethyl acetate
6. extractionThe organic extract
7. washwas washed with water
8. dry with materialdried over magnesium sulfate
9. customevaporated under reduced pressure
10. customThe residue was triturated in diisopropyl ether