Aniline → HCID 14390294, compound

HRID 621947Notes

Reaction equation

HRID 621947 reaction equation
C(Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[CH:9]=[C:10]([C:14]2[N:22]([CH2:23][C:24]([OH:26])=O)[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=2)[CH:11]=[CH:12][CH:13]=1.[NH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C(N(CC)CC)C>CN(C)C=O.O>[Cl:7][C:8]1[CH:9]=[C:10]([C:14]2[N:22]([CH2:23][C:24]([NH:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[O:26])[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=2)[CH:11]=[CH:12][CH:13]=1

Participants

7

Reactant 4

HCID 6115AnilineHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 143904542-(3-Chlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid

Product 1

HCID 14390294HCID 14390294, compoundYield 37.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent2×

Procedure

Under a nitrogen atmosphere, oxalyl chloride (4.6 g, 0.037 mole) was added dropwise (slowly) to a stirred and chilled (10°-15°° C.) solution of 2-(3-chlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid (10.0 g, 0.035 mole) in anhydrous dimethylformamide (100 ml). The reaction mixture was heated at 55°-60° C. for 5 hours, cooled to room temperature, and added dropwise to a stirred and chilled (10°-15° C.) solution of aniline (3.5 g, 0.038 mole) and triethylamine (7.6 g, 0.076 mole) in anhydrous dimethylformamide (75 ml). The reactionwas stirred dat room temperature overnight, poured into water (500 ml), allowed to precipitate, and diltered. The filter cake was twice suspended in position bicarbonate solution (250 ml) and filtered. The filter cake was washed with water, air dried, and recrystallized from ethanol, giving 4.74 g (37%) of off-white needles, mp 211°-212° C.

Workup

  1. temperatureThe reaction mixture was heated at 55°-60° C. for 5 hours
  2. additionadded dropwise to
  3. stirringa stirred
  4. stirringThe reactionwas stirred dat room temperature overnight
  5. customto precipitate
  6. filtrationfiltered
  7. washThe filter cake was washed with water, air
  8. customdried
  9. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-77515f8f312640b5bd3e640955eceabe
Source dataset
uspto-grants-1989_04
Patent number
US04824951

Reaction notes

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