Hydrochloric Acid → HCID 21292383, Verbindung

HRID 622280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 622280
[Na].CO[CH:4]=[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH:12]=[CH2:13])[CH:6]=O.Cl.[C:15]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH2:24])=[O:23])=[CH:20][CH:19]=1)(=[NH:17])[NH2:16].Cl>CO>[CH2:8]([C:5]1[CH:4]=[N:16][C:15]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH2:24])=[O:23])=[CH:20][CH:19]=2)=[N:17][CH:6]=1)[CH2:9][CH2:10][CH2:11][CH:12]=[CH2:13]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 27242934-Amidinobenzamide HydrochlorideHCID 5360545SodiumHCID 53871664HCID 53871664, Verbindung

Produkt 1

HCID 21292383HCID 21292383, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A solution of 480 mg of sodium in 17.5 ml of methanol is treated with 1.18 g of 3-methoxy-2-(5-hexenyl)acrolein and 1.62 g of 4-amidinobenzamide hydrochloride and the mixture is stirred at 50° C. overnight under nitrogen. After cooling the suspension is treated with 5.5 ml of 3N hydrochloric acid, filtered and the residue is washed with water and dried. The crude p-[5-(5-hexenyl)-2-pyrimidinyl]benzamide obtained is further processed without additional purification.

Aufarbeitung

  1. temperatureAfter cooling the suspension
  2. filtrationfiltered
  3. washthe residue is washed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a2b2e1c336c54b2ca4a417ae51b7bde7
Quelldatensatz
uspto-grants-1988_09
Patentnummer
US04770503

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