Hydrochloric Acid → HCID 21292383, compound

HRID 622280Notes

Reaction equation

HRID 622280 reaction equation
[Na].CO[CH:4]=[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH:12]=[CH2:13])[CH:6]=O.Cl.[C:15]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH2:24])=[O:23])=[CH:20][CH:19]=1)(=[NH:17])[NH2:16].Cl>CO>[CH2:8]([C:5]1[CH:4]=[N:16][C:15]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH2:24])=[O:23])=[CH:20][CH:19]=2)=[N:17][CH:6]=1)[CH2:9][CH2:10][CH2:11][CH:12]=[CH2:13]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 27242934-Amidinobenzamide HydrochlorideHCID 5360545SodiumHCID 53871664HCID 53871664, compound

Product 1

HCID 21292383HCID 21292383, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 480 mg of sodium in 17.5 ml of methanol is treated with 1.18 g of 3-methoxy-2-(5-hexenyl)acrolein and 1.62 g of 4-amidinobenzamide hydrochloride and the mixture is stirred at 50° C. overnight under nitrogen. After cooling the suspension is treated with 5.5 ml of 3N hydrochloric acid, filtered and the residue is washed with water and dried. The crude p-[5-(5-hexenyl)-2-pyrimidinyl]benzamide obtained is further processed without additional purification.

Workup

  1. temperatureAfter cooling the suspension
  2. filtrationfiltered
  3. washthe residue is washed with water
  4. customdried

Sources & evidence

ORD record
ord-a2b2e1c336c54b2ca4a417ae51b7bde7
Source dataset
uspto-grants-1988_09
Patent number
US04770503

Reaction notes

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