HCID 68283595, compound → HCID 67127466, compound

HRID 624008Notes

Reaction equation

HRID 624008 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][CH2:7][N:8]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[N:9]1>CCOC(C)=O.CCO.O=[Pt]=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][CH2:7][N:8]2[CH:12]=[C:11]([NH2:13])[CH:10]=[N:9]2)[CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 1

HCID 68283595HCID 68283595, compound

Product 1

HCID 67127466HCID 67127466, compound

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-(3-methoxyphenethyl)-4-nitro-1H-pyrazole (2.03 mmol) in EtOAc (2 mL, degassed) and EtOH (6 mL, degassed), PtO2 (45 mg, 0.20 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 3 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as red oil. LC-MS conditions A: tR=0.52 min, [M+H]+=218.42.

Workup

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-9f441f06bea84929954f7918c682aa65
Source dataset
uspto-grants-2016_04
Patent number
US09303023B2

Reaction notes

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