Tetrahydrofuran → 1-isopropyl-3-methyl-1H-1,2,4-triazole

HRID 624628Notes

Reaction equation

HRID 624628 reaction equation
[CH:1]([NH:4][N:5]=[C:6]([NH2:8])[CH3:7])([CH3:3])[CH3:2].[CH2:9](OC(OCC)OCC)C.C(N(CC)CC)C.O1CCCC1>C(O)C>[CH:1]([N:4]1[CH:9]=[N:8][C:6]([CH3:7])=[N:5]1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31214Ethyl orthoformateHCID 74037752N'-isopropylacetohydrazonamide

Product 1

HCID 207448981-isopropyl-3-methyl-1H-1,2,4-triazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N′-isopropylacetohydrazonamide 6 was treated with triethylorthoformate in ethanol, followed by triethylamine and tetrahydrofuran to give 7 (CAS Reg. No. 1401305-30-3).

Workup

  1. customto give 7 (CAS Reg

Sources & evidence

ORD record
ord-1addbd14bf194fe1a751b33466e25dd5
Source dataset
uspto-grants-2016_04
Patent number
US09303043B2

Reaction notes

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