Pyrazole → 2-Methyltetrahydrofuran

HRID 624631Notes

Reaction equation

HRID 624631 reaction equation

Br[C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH:12]=[CH:11][CH:10]=[N:9]1>C(N(CC)CC)C>[CH3:10][CH:11]1[CH2:12][CH2:2][CH2:3][O:4]1.[CH3:6][C:2]([N:8]1[CH:12]=[CH:11][CH:10]=[N:9]1)([CH3:7])[C:3]([OH:5])=[O:4]

Participants

5

Reactant 2

HCID 1048Pyrazole

HCID 749242-Bromo-2-methylpropanoic acid

Product 2

HCID 73012-Methyltetrahydrofuran

HCID 2763345alpha,alpha-Dimethyl-1H-pyrazole-1-acetic acid

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Bromo-2-methylpropanoic acid 15 and pyrazole were reacted in triethylamine and 2-methyltetrahydrofuran to give 16.

Sources & evidence

ORD record: ord-da20cd11ad064e299cea7b15e265bc16
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09303043B2

Reaction notes

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