Hydrochloric Acid → HCID 178443037, compound

HRID 625162Notes

Reaction equation

HRID 625162 reaction equation
[CH2:1]([NH2:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[ClH:18].[N:19]#[C:20][NH2:21]>C(O)CCC>[Cl-:18].[CH2:1]([NH:17][C:20]([NH2:21])=[NH2+:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8926HexadecylamineHCID 9864Cyanamide

Product 1

HCID 178443037HCID 178443037, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent2×

Conditions

Temperature
95 °C

Procedure

Hexadecylamine (3 g, 12.4 mmol) was dissolved in 1-butanol (10 ml) and 37% hydrochloric acid (1.23 g, 12.4 mmol) added. The solution was warmed to 95° C. and cyanamide (0.522 g, 12.4 mmol) dissolved in 1-butanol (20 ml) added dropwise with stirring over 10 minutes. The solution was stirred at 95° C. for a further 2 hours. Solvent was removed and the crude product crystallised from ethyl acetate to give a white solid of N-hexadecylguanidinium chloride.

Workup

  1. additionadded dropwise
  2. stirringThe solution was stirred at 95° C. for a further 2 hours
  3. customSolvent was removed
  4. customthe crude product crystallised from ethyl acetate

Sources & evidence

ORD record
ord-ffba5943d67a40e4867241a935464b48
Source dataset
uspto-grants-2016_04
Patent number
US09303201B2

Reaction notes

Loading…