反应详情

DMF (12 mL), K2CO3(1.19 g, 8.55 mmol) and benzyl bromide (0.75 mL, 6.27 mmol) was added to 4-bromo-2-fluorophenol (1.1 g, 5.7 mmol), and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was concentrated and the residue was diluted with 20 mL water. The mixture was extracted with EtOAc. The organic layer was separated and dried with MgSO4 to obtain the title compound (1.62 g, 100%).

1. customAfter the termination of the reaction
2. concentrationthe reactant was concentrated
3. additionthe residue was diluted with 20 mL water
4. extractionThe mixture was extracted with EtOAc
5. customThe organic layer was separated
6. dry with materialdried with MgSO4