反应详情

To a solution of 4-(adamantan-1-yl)phenol (2.0 g, 8.76 mmol) in N,N-dimethylformamide was added potassium carbonate (3.63 g, 26.29 mmol) and ethyl 4-bromobutanoate (1.29 g, 10.51 mmol), and stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and washed with aqueous sodium bicarbonate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was filtered and evaporated under reduced pressure to afford a crude solid, which was purified by silica gel column chromatography to give ethyl 4-(4-(adamantan-1-yl)phenoxy)butanoate as a white solid (2.7 g, 90% yield).

1. washwashed with aqueous sodium bicarbonate
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. filtrationThe solvent was filtered
4. customevaporated under reduced pressure
5. customto afford a crude solid, which
6. customwas purified by silica gel column chromatography