huagongshe.com
HRID629580

反应详情

EQUATION

反应方程式

HRID 629580 的结构方程式

REACTANTS

反应物

3
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(C)[Si](Cl)(C(C)C)C(C)C
HCID139400

Triisopropylsilyl chloride

C9H21ClSi

结构：c1ccc(COc2ccc3cc[nH]c3c2)cc1
HCID260804

6-Benzyloxyindole

C15H13NO

PRODUCTS

生成物

1
结构：CC(C)[Si](C(C)C)(C(C)C)n1ccc2ccc(O)cc21
HCID67226331

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

6-Benzyloxy-indole (1.0 g) was treated with NaH (135 mg) and triisopropylsilyl chloride (1.0 g) in tetrahydrofuran for 1 hour, purified by flash chromatography (98/2 ethyl acetate/hexanes), then debenzylated in ethanol (35 mL) using Pearlman's catalyst (0.19 g) and a hydrogen balloon.

WORKUP

后处理

  1. custompurified by flash chromatography (98/2 ethyl acetate/hexanes)