Hydrochloric Acid → 3-Amino-3-methyl-1-morpholinobutan-1-one hydrochloride

HRID 632019Notes

Reaction equation

HRID 632019 reaction equation
[CH3:1][C:2]([NH:13]C(=O)OC(C)(C)C)([CH2:4][C:5]([N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)=[O:6])[CH3:3].[ClH:21]>C(OCC)(=O)C>[ClH:21].[NH2:13][C:2]([CH3:3])([CH3:1])[CH2:4][C:5]([N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71105557tert-Butyl 2-methyl-4-morpholino-4-oxobutan-2-ylcarbamate

Product 1

HCID 710876483-Amino-3-methyl-1-morpholinobutan-1-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 2-methyl-4-morpholino-4-oxobutan-2-ylcarbamate (0.5 g, 1.7 mmol) was dissolved in a saturated solution of hydrogen chloride in ethyl acetate (20 mL). The mixture was stirred for 3 h. The solvent was removed by reduced pressure to give crude product (0.55 g).

Workup

  1. customThe solvent was removed by reduced pressure

Sources & evidence

ORD record
ord-9ca036de6a294b7abad6f9e5120cb904
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

Loading…