反应详情

温度

90 °C

To 0.85 g of 4-hydroxy-2-methyl benzoic acid methyl ester were added 12 mL of acetonitrile, 2.12 g of K2CO3 and 0.84 g of 2-(chloromethyl)pyridine hydrochloride, and the mixture was stirred at 90° C. for 4 hours. The reaction mixture was allowed to cool back to room temperature and neutralized by the addition of 5% hydrochloric acid. To this, 150 mL of AcOEt was added, and the organic layer was separated. The obtained organic layer was washed with saturated brine, dried over MgSO4, and concentrated. The residue was purified by silica gel column chromatography (hexane/AcOEt system) to give 1.18 g of the title compound (89% yield).

1. temperatureto cool back to room temperature
2. customthe organic layer was separated
3. washThe obtained organic layer was washed with saturated brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (hexane/AcOEt system)