Ethyl Acetate → HCID 118061370, compound

HRID 632791Notes

Reaction equation

HRID 632791 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1SC1C=C(C=CC=1)C(OC)=O.Cl[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([O:26]O)=[O:25])[CH:19]=1.[S:28]([O-:31])(O)=[O:29].[Na+].[C:33](OCC)(=O)C>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[S:28]([C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[C:24]([O:26][CH3:33])=[O:25])(=[O:31])=[O:29]

Participants

5

Reactant 4

HCID 8857Ethyl AcetateHCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 60023469HCID 60023469, compound

Product 1

HCID 118061370HCID 118061370, compound

Procedure

To a solution of methyl 3-(1,3-thiazol-2-ylsulfanyl)benzoate (76 mg) in ethyl acetate (1.5 mL) was added m-chloroperbenzoic acid (225 mg), and the mixture was stirred overnight at room temperature. The reaction mixture was poured into saturated aqueous sodium hydrogen sulfite solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with saturated aqueous sodium carbonate solution and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (82 mg).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed successively with saturated aqueous sodium carbonate solution and saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3be3377971524ad79f2498ac5ce9961c
Source dataset
uspto-grants-2016_04
Patent number
US09321757B2

Reaction notes

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