反应详情

温度

0 °C

Cumylamine (5.32 mL, 37.0 mmol) (TCI America) and Et3N (16.97 mL, 122 mmol) (Aldrich) were mixed in THF (40 mL) at 0° C. under a nitrogen atmosphere. Carbon disulfide (2.224 mL, 37.0 mmol) (J.T.Baker) was added dropwise via syringe over the course of 10 min. The reaction was stirred at 0° C. for 1 h before being warmed to RT and stirred for 1 h. p-Toluenesulfonyl chloride (7.76 g, 40.7 mmol) (Fluka) was added, and the reaction was stirred at RT for 1 h. The mixture was quenched with 1 M HCl and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated to give (2-isothiocyanatopropan-2-yl)benzene.

1. temperaturebefore being warmed to RT
2. additionwas added
3. stirringthe reaction was stirred at RT for 1 h
4. customThe mixture was quenched with 1 M HCl
5. extractionextracted with EtOAc
6. washThe organic layer was washed with brine
7. dry with materialdried over MgSO4
8. concentrationconcentrated